dc.contributor.author | Ong'echa, JM | |
dc.contributor.author | Raballah, EO | |
dc.contributor.author | Kempaiah, PM | |
dc.contributor.author | Anyona, SB | |
dc.contributor.author | Were, T | |
dc.contributor.author | Davenport, GC | |
dc.contributor.author | Konah, S | |
dc.contributor.author | Vulule, JM | |
dc.contributor.author | Ouma, C | |
dc.contributor.author | Hittner, JB | |
dc.contributor.author | Perkins, DJ | |
dc.date.accessioned | 2018-01-17T09:17:49Z | |
dc.date.available | 2018-01-17T09:17:49Z | |
dc.date.issued | 2011-08 | |
dc.identifier.citation | Ong’echa, J. M., Raballah, E. O., Kempaiah, P. M., Anyona, S. B., Were, T., Davenport, G. C., … Perkins, D. J. (2011). Polymorphic variability in the 3’ untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria. BMC Genetics, 12, 69. http://doi.org/10.1186/1471-2156-12-69 | en_US |
dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/122 | |
dc.description.abstract | BACKGROUND: Plasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young children that lack naturally-acquired malarial immunity, such as the population examined here. Consistent with the fact that elevated interleukin (IL)-12 is an important component of the innate immune response that provides protective immunity against malaria, we have previously shown that suppression of IL-12 in African children is associated with the development of severe malarial anaemia (SMA). Since the role of IL12B variants in conditioning susceptibility to SMA remains largely unexplored, the association between a single nucleotide polymorphism (1188A→C, rs3212227), SMA (Hb<6.0 g/dL), circulating IL-12p40/p70 levels, and longitudinal clinical outcomes in Kenyan children (n = 756) residing in a holoendemic falciparum malaria transmission area were investigated.
RESULTS: Multivariate logistic regression analysis in children with acute malaria (n = 544) demonstrated that carriers of the C allele had increased susceptibility to SMA (CC: OR, 1.674; 95% CI, 1.006-2.673; P = 0.047, and AC: OR, 1.410; 95% CI, 0.953-2.087; P = 0.086) relative to wild type (AA). Although children with SMA had lower IL-12p40/p70 levels than the non-SMA group (P = 0.037), levels did not differ significantly according to genotype. Longitudinal analyses in the entire cohort (n = 756) failed to show any significant relationships between rs3212227 genotypes and either susceptibility to SMA or all-cause mortality throughout the three year follow-up.
CONCLUSION: The rs3212227 is a marker of susceptibility to SMA in children with acute disease, but does not appear to mediate functional changes in IL-12 production or longitudinal outcomes during the acquisition of naturally-acquired malarial immunity. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Pub Med Central | en_US |
dc.title | Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria | en_US |
dc.type | Article | en_US |