| dc.contributor.author | Ogolla, Sidney | |
| dc.contributor.author | Daud, Ibrahim I | |
| dc.contributor.author | Asito, Amolo | |
| dc.contributor.author | Sumba, Odada P | |
| dc.contributor.author | Ouma, Collins | |
| dc.contributor.author | Vulule, John | |
| dc.contributor.author | Mehta, Saurabh | |
| dc.contributor.author | Rochford, Rosemary | |
| dc.date.accessioned | 2018-01-22T08:36:53Z | |
| dc.date.available | 2018-01-22T08:36:53Z | |
| dc.date.issued | 2015-11-01 | |
| dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/164 | |
| dc.description.abstract | Over 35% of children in a region of malaria endemicity are infected with Epstein-
Barr virus (EBV) by 6 months of age. This susceptibility may be linked to impaired
transplacental transfer of antibodies. In this study, we determined the effect of malaria
exposure during pregnancy on the transfer of EBV-specific maternal antibodies in a region
of western Kenya that experiences endemic malaria. Pregnant mothers were recruited and
followed up until delivery to determine levels of neonatal malaria exposure. Levels of EBV
lytic (viral capsid antigen [VCA], Z transcriptional activator [Zta], and early diffuse antigen
complex [EAd]) and EBV latent (EBV nuclear antigen-1 (EBNA1]) and tetanus-specific IgG
antibodies were measured in 70 paired maternal and cord blood samples using a Luminex-
bead-based assay. A high proportion (63%) of the infants were exposed to malaria in … | en_US |
| dc.publisher | American Society for Microbiology | en_US |
| dc.title | Reduced transplacental transfer of a subset of Epstein-Barr virus-specific antibodies to neonates of mothers infected with Plasmodium falciparum malaria during pre... | en_US |
| dc.type | Article | en_US |
