Population-specific evolution of HIV Gag epitopes in genetically diverged patients
Publication Date
2013-06-01Author
Syed H Abidi, Aniqa Shahid, Laila S Lakhani, Muhammad R Khanani, Peter Ojwang, Nancy Okinda, Reena Shah, Farhat Abbas, Sarah Rowland-Jones, Syed Ali
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Show full item recordAbstract/ Overview
Under the host selection pressure HIV evolves rapidly to override crucial steps in the antigen presentation pathway. This allows the virus to escape binding and recognition by cytotoxic T lymphocytes. Selection pressures on HIV can be unique depending on the immunogenetics of host populations. It is therefore logical to hypothesize that the virus evolving in a given population will carry signature mutations that will allow it to survive in that particular host milieu.