Polymorphic Variability in the Interleukin (IL)-1Beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1Beta Production
dc.contributor.author | Otieno, Micheal F | |
dc.contributor.author | Ouma, C | |
dc.contributor.author | Davenport, GC | |
dc.contributor.author | Awandare, GA | |
dc.contributor.author | Keller, CC | |
dc.contributor.author | Were, T | |
dc.contributor.author | Vulule, JM | |
dc.contributor.author | Martinson, J | |
dc.contributor.author | Ong'echa, JM | |
dc.contributor.author | Ferrell, RE | |
dc.contributor.author | Perkins, DJ | |
dc.date.accessioned | 2018-01-24T13:27:44Z | |
dc.date.available | 2018-01-24T13:27:44Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/250 | |
dc.description.abstract | Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1beta promoter variants (-31C/T and-511A/G), SMA (hemoglobin [Hb] level< 6.0 g/dL), and circulating IL-1beta levels were investigated in children with parasitemia (n= 566) from western Kenya. The IL-1beta promoter haplotype-31C/-511A (CA) was associated with increased risk of SMA (Hb level< 6.0 g/dL; odds ratio [OR], 1.98 [95% confidence interval {CI}, 1.55-2.27]; P<. 05) and reduced circulating IL-1beta levels (p<. 05). The TA (-31T/-511A) haplotype was nonsignificantly associated with protection against SMA (OR, 0.52 [95% CI, 0.18-1.16]; p=. 11) and elevated IL-1beta production (p<. 05) … | en_US |
dc.publisher | PubMed | en_US |
dc.title | Polymorphic Variability in the Interleukin (IL)-1Beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1Beta Production | en_US |
dc.type | Article | en_US |
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