dc.contributor.author | John M Ong’echa, Allison M Remo, Jan Kristoff, James B Hittner, Tom Were, Collins Ouma, Richard O Otieno, John M Vulule, Christopher C Keller, Gordon A Awandare, Douglas J Perkins | |
dc.date.accessioned | 2020-11-19T06:13:22Z | |
dc.date.available | 2020-11-19T06:13:22Z | |
dc.date.issued | 2008 | |
dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/2844 | |
dc.description.abstract | Severe malarial anemia (SMA) is a leading cause of mortality among children in sub-Saharan Africa. Although the novel cytokine, interleukin (IL)-23, promotes anemia in chronic inflammatory diseases, the role of IL-23 in SMA remains undefined. Since IL-23 and IL-12 share the IL-12p40 subunit and IL-12Rβ1 receptor, and are down-regulated by IL-10, relationships among these cytokines were explored in Kenyan children with varying severities of malarial anemia. Children with malarial anemia had increased circulating IL-23 and IL-10 and decreased IL-12 relative to healthy controls. Enhanced anemia severity and elevated parasitemia were associated with increased IL-10 relative to IL-23 and IL-12. Further exploration of the relationships among the cytokines using an in vitro model in which peripheral blood mononuclear cells were treated with synthetic hemozoin (sHz, malarial pigment) revealed that IL-12p35 and IL-23p19 transcripts had a sustained induction over 72 h, while IL-12p40 and IL-10 message peaked at 24 h, and rapidly declined thereafter. Taken together, results here show that IL-23 is elevated in children with malarial anemia, and that IL-10 and IL-12 appear to have important regulatory effects on IL-23 production during childhood malaria. | en_US |
dc.publisher | Academic Press | en_US |
dc.subject | Plasmodium falciparumMalarial anemiaHemozoinCytokinesIL-23IL-12IL-10 | en_US |
dc.title | Increased circulating interleukin (IL)-23 in children with malarial anemia: in vivo and in vitro relationship with co-regulatory cytokines IL-12 and IL-10 | en_US |
dc.type | Article | en_US |