Suppression of RANTES in children with Plasmodium falciparum malaria
Publication Date
2006Author
Tom Were, James B Hittner, Collins Ouma, Richard O Otieno, AS Orago, John M Ong'echa, John M Vulule, Christopher C Keller, Douglas J Perkins
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Show full item recordAbstract/ Overview
Severe malarial anemia (MA) is the primary manifestation of severe malaria among
children in areas of holoendemic Plasmodium falciparum transmission. Although overproduction of inflammatory-derived cytokines are implicated in the immunopathogenesis of severe MA, chemokines such as regulated on activation, normal T-cell expressed
and secreted (RANTES, CCL5) are largely unexplored in childhood malaria. We found
that RANTES is decreased during severe MA (p<0.01), and associated with suppression of erythropoiesis (p<0.05) and malaria-induced thrombocytopenia (p<0.05).
These findings suggest that thrombocytopenia may be a source of reduced RANTES
which may contribute, at least in part, to suppression of erythropoiesis in children with
malarial anemia.
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