dc.contributor.author | K. O. Onyango, A. K. Nyamache, G. O. Kasera, S. N. Mabeya and J. O. Nonoh | |
dc.date.accessioned | 2021-07-15T08:18:25Z | |
dc.date.available | 2021-07-15T08:18:25Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/4163 | |
dc.description.abstract | Objectives: The present study determined the prevalence of HBV/HCV coinfections; genetic diversity and drug resistance of HBV among HIV infected
patients visiting Siaya County Referral Hospital, Kenya.
Design: This was a hospital based cross-sectional study.
Setting: This study was conducted at Siaya County Referral Hospital Laboratory
and KEMRI HBV laboratory, Nairobi, Kenya.
Subjects: A total of two hundred and twenty-five (225) HIV patients randomized
from HIV comprehensive clinic of Siaya County Referral Hospital between August
and December, 2018.
Results: From the 225 samples that were analyzed, 6.2% (14/225) were HBV/HIV coinfected while that of HCV/HIV was 4.0% (9/225). However, no participant was coinfected with three viruses. Of the 11 samples that were successfully sequenced,
the phylogenetic analysis revealed the sequences belonged to HBV genotype A1.
Mutation rt169F was detected in one of the patient.
Conclusion: From this study, HBV/HCV and HIV co-infections could be higher
than reported here. HBV genotype A1 is the most predominant circulating
genotype in Siaya County. All the detected HBV were susceptible viral strains with
only one harboring HBV strain with rt169F mutation. There is therefore a need for
a continuous surveillance of HBV/HCV/HIV co-infections, circulating HBV
genotypes and drug-resistant variants in this region in order to guide vaccine and
optimization of treatment. | en_US |
dc.publisher | EAST AFRICAN MEDICAL JOURNAL | en_US |
dc.title | Hepatitis B and C virus co-infections and genetic diversity among HIV-1 infected individuals in Siaya County, Kenya | en_US |
dc.type | Article | en_US |