Show simple item record

dc.contributor.authorJew Ochola Ouma , David H. Mulama,Lucas Otieno,John Owuoth,Bernhards Ogutu,Janet Oyieko,Jackson C. Korir,Peter Sifuna,Valentine Singoei,Victorine Owira,Stacey Maureen Okallo Gondii,Ben Andagalu,Walter Otieno
dc.date.accessioned2022-01-20T10:41:06Z
dc.date.available2022-01-20T10:41:06Z
dc.date.issued2021-03-17
dc.identifier.urihttps://repository.maseno.ac.ke/handle/123456789/4413
dc.description.abstractThere is an urgent need for reliable region-specific hematological reference values for clinical monitoring. Laboratory reference ranges are important for assessing study participant eligibility, toxicity grading and management of adverse events in clinical trials and clinical diagnosis. Most clinical laboratories in Kenya rely on hematological reference values provided by instrument manufacturers and/or textbooks, which are based on population from Europe or North America. The use of such values in medical practice could result in improper patient management, selection bias in selection of appropriate participants for clinical trials and flawed classification of the clinical adverse events when applied to African populations. The aim of this study was to establish local laboratory hematological reference values in infants aged 1 month to 17 months from Kombewa Sub-county that could be true representative of the existing rural population. The study participants in the current study were those who had previously been recruited from GSK-sponsored study. This study was a phase III, Double Blind, Randomized, GSK-sponsored, Malaria Vaccine Clinical Trial that was conducted in infants aged 1month to 17months. 1,509 participants were included in the study analysis. Data were partitioned into 3 different age groups (1–6 months[m], 6–12 m and 12–17 m) and differences between gender were compared within each group. Data were analyzed using Graphpad prism V5 to generate 95% reference ranges (2.5th-97.5th percentile). There was evidence of gender differences in hemoglobin values (p = 0.0189) and platelet counts (p = 0.0005) in the 1 to 6m group. For the 12-17m group, there were differences in MCV (p<0.0001) and MCH (p = 0.0003). Comparing gender differences for all age groups, differences were noted in percent lymphocytes (p = 0.0396), percent monocytes (p = 0.0479), percent granulocytes (p = 0.0044), hemoglobin (p = 0.0204), hematocrit (p = 0.0448), MCV (p = 0.0092), MCH (p = 0.0089), MCHC (p = 0.0336) and absolute granulocytes (p = 0.0237). In 1 to 6m age group and all age groups assessed, for WBCsen_US
dc.description.sponsorship1 KEMRI/USAMRD-K, Walter Reed Project, Kisumu, Kenya, 2 Department of Biological Sciences, Masinde Muliro University of Science and Technology, Kakamega, Kenya, 3 Africa Clinical Research Management, Nairobi, Kenyaen_US
dc.publisherPublic Library of Scienceen_US
dc.subjecthematology,infants,Kombewa Sub-County, Kisumu and rural population in Western Kenyaen_US
dc.titleClinical laboratory hematology reference values among infants aged 1month to 17 months in Kombewa Sub-County, Kisumu: A cross sectional study of rural population in Western Kenyaen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record