Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans: a cross sectional study
Publication Date
2017Author
Geoffrey Omuse, Daniel Maina, Jane Mwangi, Caroline Wambua, Alice Kanyua, Elizabeth Kagotho, Angela Amayo, Peter Ojwang, Rajiv Erasmus
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Several equations have been developed to estimate glomerular filtration rate (eGFR). The common
equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease
(CKD). Some of the equations provide a correction factor for African-Americans due to their relatively increased
muscle mass and this has been extrapolated to black Africans. Studies carried out in Africa in patients with CKD
suggest that using this correction factor for the black African race may not be appropriate. However, these studies
were not carried out in healthy individuals and as such the extrapolation of the findings to an asymptomatic black
African population is questionable. We sought to compare the proportion of asymptomatic black Africans reported
as having reduced eGFR using various eGFR equations. We further compared the association between known risk
factors for CKD with eGFR determined using the different equations.
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- Department of Zoology [160]