Department of Biomedical Sciences: Recent submissions
Now showing items 21-40 of 95
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Trends of non-vaccination, under-vaccination and missed opportunities for vaccination (2003–2014) amongst children 0–23 months in Kenya
(Public Library of Science, 2024-02-06)Vaccines are effective and cost-effective. Non-vaccination, under-vaccination, and missed opportunities for vaccination (MOV), have contributed to incomplete vaccination coverage in Kenya. Analyzing their trends is essential ... -
Coagulation hallmark indicators of menorrhagia in a comparative study between menorrhagic and healthy women attending Bungoma County Referral Hospital in Kenya
(Research Square, 2024-02-13)Despite the significant burden of menorrhagia among women in Western Kenya, it remains unknown whether coagulation disorders are one of the important underlying causes of this condition in the region. This study evaluated ... -
Factors influencing patients’ adherence to malaria Artemisinin-based combination therapy treatment in Kamuli District, Uganda
(Research Square, 2023-10-06)Patients’ adherence to prescribed Artemisinin-based Combination Therapy (ACT) treatment is a key malaria control strategy. To accelerate and realize a malaria free country, malaria management measures remain a key public ... -
Comparison of Different Trapping Methods to Collect Malaria Vectors Indoors and Outdoors in Western Kenya
(Research square, 2023-08-31)Enhanced vector surveillance, is one of the 4 pillars of the WHO’s global vector control response (2017–2030). Human landing catches are the gold standard for entomological surveys but are difficult to implement and expose ... -
Health Providers’ Self Reported Provision of Preconception Care and Associated Factors in Kisumu County-kenya
(Research square, 2023-09-01)Preconception care (PCC) is the provision of health interventions to women and couples before conception occurs and is valuable in preventing and controlling noncommunicable diseases. In Africa, more so in Kenya, maternal ... -
Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia
(BioMed Central, 2023-09-13)Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) < 5.0 g/dL in children] is the most common clinical ... -
Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya
(BioMed Central, 2023)Epstein Barr virus (EBV)-associated endemic Burkitt’s Lymphoma pediatric cancer is associated with morbidity and mortality among children resident in holoendemic Plasmodium falciparum regions in western Kenya. P. falciparum ... -
Profiling genome-wide recombination in Epstein Barr virus reveals type-specific patterns and associations with endemic-Burkitt lymphoma
(BioMed Central, 2022-12)Endemic Burkitt lymphoma (eBL) is potentiated through the interplay of Epstein Barr virus (EBV) and holoendemic Plasmodium falciparum malaria. To better understand EBV’s biology and role in eBL, we characterized genome-wide ... -
Clinical malaria incidence and health seeking pattern in geographically heterogeneous landscape of western Kenya
(BioMed Central, 2022)Malaria remains a public health problem in Kenya despite sustained interventions deployed by the government. One of the major impediments to effective malaria control is a lack of accurate diagnosis and effective treatment. ... -
Antimicrobial Resistance Patterns of Bacteria Isolated from Wounds of Diabetic Patients at Jaramogi Oginga Odinga Teaching & Referral Hospital (JOOTRH), Kenya
(EJMED, 2022)The purpose of this study was to determine antimicrobial resistance patterns of bacteria isolated from wounds of diabetes mellitus patients at JOOTRH. A hospital based cross sectional study design was employed with a target ... -
Impact of integrated water, sanitation, hygiene, health and nutritional interventions on diarrhoea disease epidemiology and microbial quality of water in a resource-constrained setting in Kenya: A controlled intervention study
(Wiley online library, 2022)We assessed the impact of water, hygiene and sanitation (WASH), maternal,new-born and child health (MNCH), nutrition and early childhood development (ECD) on diarrhoea and microbial quality of water in a resource-constrained ... -
Genetic differentiation in East African ethnicities and its relationship with endurance running success
(Public Library of Science, 2022)Since the 1960s, East African athletes, mainly from Kenya and Ethiopia, have dominated long-distance running events in both the male and female categories. Further demographic studies have shown that two ethnic groups are ... -
Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility to Plasmodium falciparum infections and severe malarial anemia in kenyan children
(Frontiers, 2022)Severe malarial anemia (SMA; Hb < 5.0 g/dl) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions such as western Kenya. -
The prevalence and management strategies of gestational urinary tract infections (UTI) in Kisumu County, Kenya
(Cold Spring Harbor Laboratory Press, 2022)Urinary tract infections (UTI) contribute to substantive proportions of adverse pregnancy outcomes. Current national statistics in Kenya show high maternal mortality (488/100,000) and neonatal mortality (24/1,000) rates. ... -
Prevalence of preconception care provision in Kisumu county-Kenya
(Cold Spring Harbor Laboratory Press, 2022)‘Preconception care’ (PCC) is the provision of biomedical, behavioral and social health interventions to women and couples before conception occurs. The PCC, is valuable and key in preventing and controlling non-communicable ... -
Evidence of co-exposure with Brucella spp, Coxiella burnetii, and Rift Valley fever virus among various species of wildlife in Kenya
(Public Library of Science, 2022-09)Co-infection, especially with pathogens of dissimilar genetic makeup, may result in a more devastating impact on the host. Investigations on co-infection with neglected zoonotic pathogens in wildlife are necessary to ... -
Influence of landscape heterogeneity on entomological and parasitological indices of malaria in Kisumu, Western Kenya
(BioMed Central, 2022)Identification and characterization of larval habitats, documentation of Anopheles spp. composition and abundance, and Plasmodium spp. infection burden are critical components of integrated vector management. The present ... -
Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya
(BioMed Central, 2022)Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1, the colony-stimulating factor 2 gene (CSF2) encodes granulocyte ... -
Sero-Prevalence and Molecular Analysis of Brucellosis in Livestock Keepers and Domestic Ruminants in Baringo County, Kenya
(Research square, 2022)Brucellosis is widely distributed in more than 170 countries around the world, where it poses a huge threat to animal husbandry and human health. Brucellosis is a worldwide re-emerging zoonotic disease that poses serious ... -
Molecular basis of reduced LAIR1 expression in childhood severe malarial anaemia: Implications for leukocyte inhibitory signalling
(science direct, 2019)Leukocyte-associated immunoglobulin like receptor-1 (LAIR1) is a transmembrane inhibitory receptor that influences susceptibility to a myriad of inflammatory diseases. Our recent investigations of severe malarial anaemia ...