| dc.description.abstract | Global shift to high energy foods is important risk factor for new variants of
prostate cancer. Some prostate tumors have an indolent course while others have an aggressive
course; therefore, knowledge of tumor subtypes can help in clinical decision-making based on the
patient profile. Methods: The main aim of the study was to determine the histomorphological
characteristics of prostate specimens analyzed at regional referral hospital. The study was a crosssectional retrospective study. The target specimens in this study consisted of prostate specimens
that had prostate specific antigen level and were analyzed and reported between 2017 and 2022
at Jaramogi Odinga Oginga teaching and referral hospital, Kisumu Kenya. Results: Prostate color
was not reported in eight reports. Of the 72 specimens observed, 50 (69.4%) were reported to
be white, 12 (16.7%) were reported to be tan/white, 9 (12.5%) were tan brown, and 1 (1.4%)
was tan grey. There was significant variation (p=0.001) in prostate specimen color. Of the 80
specimens, 47 (58.75%) had coarse surface, 16(20.00%) nodulated surfaces and 17 (21.25%)
shrunken surfaces. There was variation in prostate surfaces (p<0.00001, X
2=23.275). Majority of
specimens 55 (68.8%) measured between 0-29 mm, 12 (15%) measured 30-59 mm, 7 (8.8%)
measured 60-89, 3 (3.8%) measured 90-119, 2 (2.5%) measured >150 mm and 1 (1.3%)
measured 120-149 mm. There was no significant difference in the prostate biopsy sizes in
comparison to the mean (p=0.984, t=0.020, 95% CI). The majority 20 (25%), of specimens had
prostate cancer 15 (18.75%) had atypical findings, and 2 (2.5%) had high-grade proliferative
intraepithelial neoplasia. The microscopic features of the groups did not differ significantly (F2,
34 = 1.469, p = 0.244). There is positive correlation between Gleason scores and Prostate specific
antigen levels (p = 0.004, r = 0.474). Conclusion: There is variation of specimen color in
prostate specimen with prostate cancer implying that advanced prostate disease causes changes
in prostate color. Atypical prostate findings are common in age 50-59 which may suggest that
targeted prevention and intervention should focus on this age group. Higher Gleason scores are
likely to be observed in patients with higher PSA levels among patients being evaluated for
prostate tumors. | en_US |
