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Clinical Predictors of Severe Malarial Anemia in a Holoendemic P. Falciparum Transmission Area
(2005)
Severe malarial anaemia (SMA) is a common complication of Plasmodium falciparum
infections, resulting in mortality rates that may exceed 30% in paediatric populations
residing in holoendemic transmission areas. One ...
Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria
(AIDS, 2005)
Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria
Turning point
(Nature Research, 2011-02-01)
Collins Ouma became a molecular biologist to help thwart malaria's high mortality rate in his
native Kenya. Last November, he won the Royal Society Pfizer award for his work on
identifying genes that may confer protection ...
Functional Haplotypes of Fc Gamma (Fcy) Receptor (FcyRIIA and FcyRIIB) Predict Risk to Repeated Episodes of Severe Malarial Anaemia and Mortality in Kenyan...
(SN Konah, 2012)
Development of protective immunity against Plasmodium falciparum is partially mediated
through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variations in human
FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect ...
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.
(PubMed, 2012)
Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children
residing in regions where plasmodium falciparum transmission is holoendemic. Although
largely unexplored in children with SMA, ...
Polymorphic Variability in the Interleukin (IL)-1Beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1Beta Production
(PubMed, 2012)
Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to
Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in
conditioning the immunopathogenesis of severe ...
Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults
(Immunogenetics, 2012)
Polymorphic variability in immune response genes, such as IL12B, encoding the IL-12p40
subunit is associated with susceptibility to severe malaria in African populations. Since the
role of genetic variation in conditioning ...
MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia
(Journal of Infectious Diseases, 2012)
Severe malarial anemia (SMA) resulting from Plasmodium falciparum
infection is one of the leading causes of childhood mortality in sub-Saharan Africa. The
innate immune mediator macrophage migration inhibitory factor ...
Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region
(Nature Publishing Group, 2020-01)
Cyclooxygenase-2 [(COX-2) or prostaglandin endoperoxide H2 synthase-2 (PTGS-2)] induces the production of prostaglandins as part of the host-immune response to infections. Although a number of studies have demonstrated the ...
Shorter interval and multiple flooding-drying cycling enhanced the mineralization of 14C-DDT in a paddy soil
(Elsevier, 2019-08-01)
DDT and its main metabolites (DDTs) are still the residual contaminants in soil. Sequential anaerobic-aerobic cycling has long been approved for enhancing the degradation of DDTs in soil. However, there is a lack of study ...