School of Medicine: Recent submissions
Now showing items 101-120 of 560
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Case report: Acute Kidney Injury, Liver impairment, Severe Anemia in a child with Malaria and Hyperparasitaemia
(Peertechz, 2021-01-19)Severe Malaria is a medical emergency mainly because of its rapid progression to complications and death if not promptly and adequately treated. In 2018 WHO put the incidence of P. falciparum Malaria in the African region ... -
Clinical laboratory hematology reference values among infants aged 1month to 17 months in Kombewa Sub-County, Kisumu: A cross sectional study of rural population in Western Kenya
(Public Library of Science, 2021-03-17)There is an urgent need for reliable region-specific hematological reference values for clinical monitoring. Laboratory reference ranges are important for assessing study participant eligibility, toxicity grading and ... -
Baseline incidence of meningitis, malaria, mortality and other health outcomes in infants and young sub-Saharan African children prior to the introduction of the RTS, S/AS01E …
(BioMed Central, 2021-04-26)The lack of background disease incidence rates in sub-Saharan countries where the RTS,S/AS01E malaria vaccine is being implemented may hamper the assessment of vaccine safety and effectiveness. This study aimed to document ... -
Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya
(BioMed Central, 2021-12)In Plasmodium falciparum infection, clinical conditions such as anaemia, thrombocytopenia and leukocytosis are common. Mutation in haemoglobin sub-unit beta gene (HBB) may be a genetic factor responsible for these ... -
Caffeine for the care of preterm infants in sub-Saharan Africa: a missed opportunity?
(BMJ Specialist Journals, 2021-12-01)In 2019, 2.4 million neonates (infants< 28 days of age) died globally. Of these, over 80% were preterm infants (< 37 weeks gestation), with the majority born in low-income and middle-income countries. 1 Complications of ... -
Enteral Feeding Practices for Very Preterm and Very Low Birth Weight Infants in Nigeria and Kenya
(Frontiers in pediatrics, 2022-05-11)Optimizing nutrition in very preterm (28–32 weeks gestation) and very low birth weight (VLBW; 1,000 g to< 1,500 g) infants has potential to improve their survival, growth, and long-term health outcomes. Aim To assess ... -
Assessing the safety, impact and effectiveness of RTS, S/AS01E malaria vaccine following its introduction in three sub-Saharan African countries: methodological approaches and …
(BioMed Central, 2022-12)Following a 30-year development process, RTS,S/AS01E (GSK, Belgium) is the frst malaria vaccine to reach Phase IV assessments. The World Health Organization-commissioned Malaria Vaccine Implementation Pro‑ gramme (MVIP) ... -
Data-independent acquisition mass spectrometry in severe rheumatic heart disease (RHD) identifies a proteomic signature showing ongoing inflammation and effectively classifying RHD cases
(BioMed Central, 2022)Background Rheumatic heart disease (RHD) remains a major source of morbidity and mortality in developing countries. A deeper insight into the pathogenetic mechanisms underlying RHD could provide opportunities for drug ... -
Linking private health sector to public COVID-19 response in Kisumu, Kenya: Lessons Learnt
(Cold Spring Harbor Laboratory Press, 2022)COVID-19 is overwhelming health systems universally. Increased capacity to combat the epidemic is important, while continuing regular healthcare services. This paper describes an innovative Public Private Partnership (PPP) ... -
Efficacy of Thermal Ablation for Treatment of High-Grade Cervical Dysplasia Among HIV-Positive Women: Preliminary Results From Western Kenya
(Wolters Kluwer Health, 2022)In 2019, the World Health Organization (WHO) endorsed thermal ablation (TA) for use within “screen-and-treat” cervical cancer prevention programs in low- and middle-income countries (LMICs), including among women living ... -
Validation of Chloe SED, a Low-Cost, Reusable Syringe Extension Device for the Provision of Paracervical Analgesia [A21]
(LWW, 2022)Women in Kenya and other low- and middle-income countries often do not receive analgesia during manual vacuum aspiration (MVA). This pilot study evaluated the efficacy of a novel, ultra-low-cost syringe extension device ... -
A Comprehensive COVID-19 Daily News and Medical Literature Briefing to Inform Health Care and Policy in New Mexico: Implementation Study
(JMIR Publications Inc., Toronto, Canada, 2022)Background: On March 11, 2020, the New Mexico Governor declared a public health emergency in response to the COVID-19 pandemic. The New Mexico medical advisory team contacted University of New Mexico (UNM) faculty to form ... -
Design of a novel online, modular, flipped-classroom surgical curriculum for East, Central, and Southern Africa
(LWW, 2022)Objective: We describe a structured approach to developing a standardized curriculum for surgical trainees in East, Central, and Southern Africa (ECSA). Summary Background Data: Surgical education is essential to ... -
Data-independent acquisition mass spectrometry in severe rheumatic heart disease (RHD) identifies a proteomic signature showing ongoing inflammation and effectively classifying RHD cases
(BioMed Central, 2022)Rheumatic heart disease (RHD) remains a major source of morbidity and mortality in developing countries. A deeper insight into the pathogenetic mechanisms underlying RHD could provide opportunities for drug repurposing, ... -
Explanatory models, illness, and treatment experiences of patients with psychosis using the services of traditional and faith healers in three African countries: Similarities …
(SAGE Publications, 2021)As part of formative studies to design a program of collaborative care for persons with psychosis, we explored personal experience and lay attributions of illness as well as treatment among persons who had recently received ... -
Modifying Group Interpersonal Psychotherapy for Peripartum Adolescents in Sub-Saharan African Context: Reviewing Differential Contextual and Implementation Considerations
(SAGE Publications, 2022)This study describes adaptation and modification of World Health Organization (WHO) recommended group interpersonal psychotherapy (IPT-G) for depressed peripartum adolescents. The adaptation process includes accommodating ... -
Proteotyping as alternate typing method to diferentiate Campylobacter coli clades
(2019)Besides Campylobacter jejuni, Campylobacter coli is the most common bacterial cause of gastroenteritis worldwide. C. coli is subdivided into three clades, which are associated with sample source. Clade 1 isolates are ... -
COVID-19’s threat to the progress in the fight against female genital mutilation in Africa
(Elsevier, 2021)he COVID-19 pandemic has been affecting all aspects of peoples’ lives globally, impacting the socio-economic, cultural, health and educational aspects of lives. One of these socio-economic, cultural and health aspects of ... -
Ruptured Obturator Internus Muscle Abscess Causing Extensive Retroperitoneal Necrosis
(Hindawi, 2020)Obturator internus muscle (OIM) abscess occurs rarely in adults. Accurate diagnosis is often hindered and delayed due to the deep location of the abscess and the nonspecific clinical features. Even of rarer occurrence is ... -
Performance of a rapid antigen test for SARS-CoV-2 in Kenya
(Elsevier, 2022)Testing for SARS-CoV-2 in resource-poor settings remains a considerable challenge. Gold standard nucleic acid tests are expensive and depend on availability of expensive equipment and highly trained laboratory staff. ...