School of Medicine: Recent submissions
Now showing items 81-100 of 560
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Food Security Status During The Covid-19 Pandemic Among Vulnerable Groups In Keiyo South, Elgeyo Marakwet County, Kenya
(International Journal of Scientific and Research Publications, 2021)Health guidelines to manage the COVID-19 pandemic could have led to unintended changes in states and processes that affect food systems, food security, and nutrition. The study conducted in Elgeyo Marakwet County, Kenya ... -
Healthcare provider and pregnant women’s perspectives on the implementation of intermittent screening and treatment with dihydroartemisinin–piperaquine for malaria in pregnancy in western Kenya: a qualitative study
(BioMed Central, 2021)In malaria endemic regions in Kenya, pregnant women are ofered long-lasting insecticidal nets and intermittent preventive treatment (IPTp) with sulfadoxine–pyrimethamine (SP) at antenatal care (ANC) to prevent the adverse ... -
Immunohistochemical Analysis of Prostein in Needle Core Biopsies of Acinar and Intraductal Prostatic Adenocarcinoma in Western Kenya Population
(Fortune Journals, 2022)Prostein is a newly reported prostate cancer biomarker. Nonetheless, no reports on African population are available. The current study aimed to determine the prostein expression in archived prostatic core biopsies in Western ... -
Expression of IL-6 receptor correlates with Gleason grade for patients with prostatic acinar adenocarcinoma in Kisumu Specialist Hospital in Kisumu County, Western Kenya
(2022)The potential roles of inflammatory makers in prostate cancer are subjects of intense examination and Interleukin-6 receptor (IL-6R) is key in these processes. Expression of interleukin-6 Receptor (IL-6R) has not been ... -
Association between prostein immune-histochemical expression and histo-pathological grading of prostate cancer urology clinics in Kisumu city experience
(AJOL, 2022)The degree of morphological differentiation on histological assessment is a limited prediction of PCa aggressiveness. Prostein is being evaluated as additional biomarker in diagnosis and prognostication of prostate cancer. -
Validation of Chloe SED, a Low-Cost, Reusable Syringe Extension Device for the Provision of Paracervical Analgesia [A21]
(LWW, 2022)Women in Kenya and other low- and middle-income countries often do not receive analgesia during manual vacuum aspiration (MVA). This pilot study evaluated the efficacy of a novel, ultra-low-cost syringe extension device ... -
Development and initial validation of a pictorial survey to assess for symptomatic pelvic organ prolapse and urinary incontinence in western Kenya
(Springer International Publishing, 2022)Visual tools are a valuable tool for ascertaining patient symptoms, especially in populations with low literacy rates. The objective was to develop and validate a pictorial scale for assessing symptomatic pelvic organ ... -
Profiles of Isoniazid and Rifampicin drug resistance conferring mutations in Mycobacterium tuberculosis among new and previously treated pulmonary tuberculosis cases from Kisumu County, Kenya
(East African Journal of Science, Technology and Innovation, 2022)Mycobacterium tuberculosis infection is one of the leading causes of mortality and morbidity in developing countries and drug resistance remains a challenge. Drug resistance is hastened by point mutations in the bacilli ... -
Burden of malaria in pregnancy among adolescent girls compared to adult women in 5 sub-Saharan African countries: A secondary individual participant data meta-analysis of 2 clinical trials
(PLOS MEDICINE, 2022)Malaria is among the top causes of death in adolescent girls (10 to 19 years) globally. Adolescent motherhood is associated with increased risk of adverse maternal and neonatal outcomes. The interaction of malaria, ... -
Adverse effects of Lugol’s iodine: Heart failure in a patient with subcutaneous phycomycosis from a resource-limited setting
(Elsevier, 2022-09-09)Subcutaneous phycomycosis becomes a chronic, debilitating condition if left untreated. Treatment includes oral antifungal therapy, though oral potassium iodide has been used in resource-limited settings. Lugol's iodine has ... -
Isoniazid and Rifampicin Tuberculosis Drug Resistance in HIV Endemic Region of Western Kenya
(East Africa Science, 2022-03)Tuberculosis drug resistance is often associated with inadequate anti-tuberculosis treatment regimen resulting to mutations that confers resistance to anti-tuberculosis agents. This is aggravated by synergetic relationship ... -
Assessing the safety, impact and effectiveness of RTS,S/AS01E malaria vaccine following its introduction in three sub-Saharan African countries: methodological approaches and study set-up
(BioMed Central, 2022)Following a 30-year development process, RTS,S/AS01E (GSK, Belgium) is the first malaria vaccine to reach Phase IV assessments. The World Health Organization-commissioned Malaria Vaccine Implementation Programme (MVIP) is ... -
Safety profile of the RTS, S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa
(Taylor & Francis, 2019-10-03)A phase III, double-blind, randomized, controlled trial (NCT00866619) in sub-Saharan Africa showed RTS, S/AS01 vaccine efficacy against malaria. We now present in-depth safety results from this study. 8922 children ... -
Estimating Annual Fluctuations in Malaria Transmission Intensity and in the Use of Malaria Control Interventions in Five Sub-Saharan African Countries
(The American Society of Tropical Medicine and Hygiene, 2020)RTS,S/AS01E malaria vaccine safety, effectiveness, and impact will be assessed in pre- and post-vaccine introduction studies, comparing the occurrence of malaria cases and adverse events in vaccinated versus unvaccinate ... -
Safety and immunogenicity of the RTS, S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in sub-Saharan Africa
(Elsevier, 2020-01-22)We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducted in seven sub-Saharan African ... -
Estimating annual fluctuations in malaria transmission intensity and in the use of malaria control interventions in five sub-Saharan African countries
(The American Society of Tropical Medicine and Hygiene, 2020-11)RTS, S/AS01 E malaria vaccine safety, effectiveness, and impact will be assessed in pre-and post-vaccine introduction studies, comparing the occurrence of malaria cases and adverse events in vaccinated versus unvaccinated ... -
Immunophenotypic Characterization of ART-naive, HIV Infected Adults in Kombewa Sub-county, Kisumu: A Cross Sectional Study of Rural Population in Western Kenya
(Journal of Clinical Immunology and Research, 2020-11-12)Reliable information on clinical immunophenotypic biomarkers is critical in the management of Hepatitis B and C infections especially in ART naive HIV positive adults. CD4 cell counts and the level of liver function ... -
Case Report: An unusual case of bee envenomation presenting with acute kidney injury, cavernous venous thrombosis and multiple episodes of convulsions
(Peertechz, 2020-11-07)Bee stings are common in the tropics and cause minor problems but may occasionally cause severe anaphylactoid reactions. Summary of clinical case: We present a case of M.O.O., an 8-year-old boy who was stung three times ... -
Association between haematological parameters and sickle cell genotypes in children with Plasmodium falciparum malaria resident in Kisumu County in Western Kenya
(BioMed Central, 2020-12)Sickle cell disease (SCD) is a monogenic disorder due to point mutation in the β-globin gene resulting in substitution of Valine for Glutamic acid. The SCD is prevalent in P. falciparum endemic regions such as western ... -
Burden of disease and risk factors for mortality amongst hospitalized newborns in Nigeria and Kenya
(Public Library of Science, 2021-01-14)Objective To describe the patient population, priority diseases and outcomes in newborns admitted <48 hours old to neonatal units in both Kenya and Nigeria. Study design In a network of seven secondary and tertiary level ...