School of Medicine: Recent submissions
Now showing items 181-200 of 560
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Immunophenotypic Characterization of ART- naive, HIV Infected Adults in Kombewa Sub-county, Kisumu: A Cross Sectional Study of Rural Population in Western Kenya
(Journal of Clinical Immunology and Research, 2020)Reliable information on clinical immunophenotypic biomarkers is critical in the management of Hepatitis B and C infections especially in ART naive HIV positive adults. CD4 cell counts and the level of liver function ... -
Case Report: An unusual case of bee envenomation presenting with acute kidney injury, cavernous venous thrombosis and multiple episodes of convulsions
(peertechzpublications, 2020)Bee stings are common in the tropics and cause minor problems but may occasionally cause severe anaphylactoid reactions -
Baseline incidence of meningitis, malaria, mortality and other health outcomes in infants and young sub-Saharan African children prior to the introduction of the RTS,S/AS01E malaria vaccine
(BioMed Central, 2021)The lack of background disease incidence rates in sub-Saharan countries where the RTS,S/AS01E malaria vaccine is being implemented may hamper the assessment of vaccine safety and efectiveness. This study aimed to document ... -
Differential Gene Expression in Host Ubiquitination Processes in Childhood Malarial Anemia
(Frontiers Media SA, 2021): Malaria remains one of the leading global causes of childhood morbidity and mortality. In holoendemic Plasmodium falciparum transmission regions, such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < ... -
Modelling the relationship between malaria prevalence as a measure of transmission and mortality across age groups
(BioMed Central, 2019): Parasite prevalence has been used widely as a measure of malaria transmission, especially in malaria endemic areas. However, its contribution and relationship to malaria mortality across diferent age groups has not been ... -
Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: development of study site infrastructure and lessons learned
(BioMed Centra, 2019)Malaria transmission is high in western Kenya and the asymptomatic infected population plays a signifcant role in driving the transmission. Mathematical modelling and simulation programs suggest that interventions targeting ... -
National stakeholder preferences for next-generation rotavirus vaccines: Results from a six-country study
(Elsevier, 2021)Currently available live, oral rotavirus vaccines (LORVs) have significantly reduced severe rotavirus hospitalizations and deaths worldwide. However, LORVs are not as effective in low- and middle-income countries (LMIC) ... -
Pediatric Reference Values for Some Renal Biochemistry Tests in Meru County, Kenya
(International Journal of Bioprocess & Biotechnological Advancements, 2019)International Journal of Bioprocess & Biotechnological Advancements -
Assessment of submicroscopic infections and gametocyte carriage of Plasmodium falciparum during peak malaria transmission season in a community-based cross-sectional survey in western Kenya, 2012
(BioMed Central, 2016)Although malaria control intervention has greatly decreased malaria morbidity and mortality in many African countries, further decline in parasite prevalence has stagnated in western Kenya. In order to assess if malaria ... -
Impact of sulfadoxine-pyrimethamine resistance on effectiveness of intermittent preventive therapy for malaria in pregnancy at clearing infections and preventing low birth weight
(Oxford University Press, 2016-02-01)Owing to increasing sulfadoxine-pyrimethamine (SP) resistance in sub-Saharan Africa, monitoring the effectiveness of intermittent preventive therapy in pregnancy (IPTp) with SP is crucial -
Factors affecting antenatal care attendance: results from qualitative studies in Ghana, Kenya and Malawi
(Public Library of Science, 2013-01-15)Antenatal care (ANC) is a key strategy to improve maternal and infant health. However, survey data from subSaharan Africa indicate that women often only initiate ANC after the first trimester and do not achieve the ... -
Burden of disease and risk factors for mortality amongst hospitalized newborns in Nigeria and Kenya
(Public Library of Science, 2021-01-14)To describe the patient population, priority diseases and outcomes in newborns admitted <48 hours old to neonatal units in both Kenya and Nigeria. -
Case report: Acute Kidney Injury, Liver impairment, Severe Anemia in a child with Malaria and Hyperparasitaemia
(Global journal of medical and clinical case reports, 2021-01-19)Severe Malaria is a medical emergency mainly because of its rapid progression to complications and death if not promptly and adequately treated. In 2018 WHO put the incidence of P. falciparum Malaria in the African region ... -
Clinical laboratory hematology reference values among infants aged 1month to 17 months in Kombewa Sub-County, Kisumu: A cross sectional study of rural population in Western Kenya
(Public Library of Science, 2021-03-17)There is an urgent need for reliable region-specific hematological reference values for clinical monitoring. Laboratory reference ranges are important for assessing study participant eligibility, toxicity grading and ... -
Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya
(Springer, 2021)In Plasmodium falciparum infection, clinical conditions such as anaemia, thrombocytopenia and leukocytosis are common. Mutation in haemoglobin sub-unit beta gene (HBB) may be a genetic factor responsible for these ... -
Caffeine for the care of preterm infants in sub- Saharan Africa: a missed opportunity?
(BMJ Specialist Journals, 2021)In 2019, 2.4 million neonates (infants <28 days of age) died globally. Of these, over 80% were preterm infants (<37 weeks gestation), with the majority born in low- income and middle- income countries.1 Complications of ... -
Phytochemistry and insecticidal activity of Annona mucosa leaf extracts against Sitophilus zeamais and Prostephanus truncatus
(Journal of Asian Natural Products Researc, 2021)A new oleanane type triterpene characterized as 3α, 24-diacetoxy-12-oleanene (1) together with known compounds 2-10, were isolated from Annona mucosa leaf extracts. Their structural elucidation was accomplished using ... -
Enhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial
(Elsevier, 2021)Risk of mortality following surgery in patients across Africa is twice as high as the global average. Most of these deaths occur on hospital wards after the surgery itself. We aimed to assess whether enhanced postoperat ... -
Predictors of Ocular Surface Squamous Neoplasia and Conjunctival Squamous Cell Carcinoma among Ugandan Patients: A Hospital-based Study
(Wolters Kluwer--Medknow Publications, 2018)AIM: The aim of the study was to assess the predictors of ocular surface squamous neoplasia (OSSN) and conjunctival squamous cell carcinoma (SCC) among Ugandan patients. MATERIALS AND METHODS: Patients presenting for ... -
The management of microbial keratitis within Uganda’s primary health system: a situational analysis
(The Wellcome Trust, 2019)Background: Microbial keratitis (MK) frequently leads to sight-loss, especially when the infection is severe and/or appropriate treatment is delayed. The primary health system as an entry point plays a central role in ...