School of Medicine: Recent submissions
Now showing items 341-360 of 560
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Health care seeking behavior among caregivers of sick children who 2 had severe malarial anaemia 3
(maseno university, 2015)Aims: The western region in Kenya is holoendemic to malaria and experience stable P. falciparum malaria transmission. The use of health care options has a direct influence on the outcome of severe malaria. As such, the ... -
Perspectives of Women on Strategies to Improve the Number of Male Partners Testing for HIV at the Antenatal Clinic in Western Kenya, 2015.
(International Journal of Scientific and Research Publications,, 2015)- Mother to child transmission of HIV (MTCT) remains a significant public health problem in Western Kenya. Male partner testing at the antenatal clinic (ANC) has been cited as a key strategy to reduce MTCT. The Western ... -
Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya
(BioMed Central, 2005)Background: It has been hypothesized that the African alleles Sl2 and McCb of the Swain-Langley (Sl) and McCoy (McC) blood group antigens of the complement receptor 1 (CR1) may confer a survival advantage in the setting ... -
Association between sickle cell trait and low density parasitaemia among asymptomatic and parasitaemic individuals living in P. falciparum malaria Holoendemic region of Western …
(SDI, 2008)The frequency of the mutant gene for sickle cell is widely distributed in the sub-Saharan Africa, the Middle East and the Indian subcontinent. There is epidemiologic evidence that sickle cell trait confers a survival ... -
Distinct pattern of class and subclass antibodies in immune complexes of children with cerebral malaria and severe malarial anaemia
(Blackwell Publishing Ltd, 2008)Plasmodium falciparum infection can lead to deadly complications such as severe malaria‐associated anaemia (SMA) and cerebral malaria (CM). Children with severe malaria have elevated levels of circulating immune complexes ... -
Bullous erythema multiforme after treatment with Malarone®, a combination antimalarial composed of atovaquone and proguanil hydrochloride
(SAGE Publications, 2008)We report on a Kenyan woman who developed bullous erythema multiforme, in association with Malarone treatment. -
COMPLEMENT REGULATORY PROTEIN LEVELS IN CHILDREN WITH SICKLE CELL TRAIT
(Nairobi university, 2009)Sickle cell disease refers to a collection of autosomal recessive genetic disorders characterized by the presence of HbS variant of the globin chain while “sickle cell anaemia” refers to individuals with two copies of the ... -
Clinical and molecular evidence for a case of Buruli ulcer (Mycobacterium ulcerans infection) in Kenya
(The American Society of Tropical Medicine and Hygiene, 2009)Mycobacterium ulcerans infection is an emerging disease that causes indolent, necrotizing skin lesions known as Buruli ulcer (BU) and occasional contiguous or metastatic bone lesions. Buruli ulcer is named after Buruli ... -
The levels of CD16/Fc gamma receptor III A on CD14+CD16+ monocytes are higher in children with severe Plasmodium falciparum anemia than in children with …
(BioMed Central, 2010)Fc gamma receptor IIIA (CD16/FCγRIIIA) on monocytes/macro-phages may play an important role in the pathogenesis of severe malarial anemia (SMA) by promoting phagocytosis of IgG-coated uninfected red cells and by allowing ... -
Increased deposition of C3b on red cells with low CR1 and CD55 in a malaria-endemic region of western Kenya: Implications for the development of severe anemia
(BioMed Central, 2010)Severe anemia due to Plasmodium falciparum malaria is a major cause of mortality among young children in western Kenya. The factors that lead to the age-specific incidence of this anemia are unknown. Previous studies have ... -
The Levels of CD16/Fcγ Receptor IIIA on CD14+ CD16+ Monocytes Are Higher in Children with Severe Plasmodium falciparum Anemia than in Children with Cerebral or Uncomplicated Malaria
(American Society for Microbiology Journals, 2010)Fc gamma receptor IIIA (CD16/FcγRIIIA) on monocytes/macrophages may play an important role in the pathogenesis of severe malarial anemia (SMA) by promoting phagocytosis of IgG-coated uninfected red cells and by allowing ... -
The levels of CD16/Fc gamma receptor III A on CD14+CD16+ monocytes are higher in children with severe Plasmodium falciparum anemia than in children with …
(BioMed Central, 2010)Fc gamma receptor IIIA (CD16/FCgRIIIA) on monocytes/macro-phages may play an important role in the pathogenesis of severe malarial anemia (SMA) by promoting phagocytosis of IgG-coated uninfected red cells and by allowing ... -
Dual role of erythrocyte complement receptor type 1 in immune complex‐mediated macrophage stimulation: implications for the pathogenesis of Plasmodium falciparum malaria
(Blackwell Publishing Ltd, 2011)iven the ability of erythrocytes to bind immune complexes (ICs), we postulated that they can serve a dual role during inflammatory or infectious processes. Erythrocytes could restrict stimulation of macrophages by free ICs ... -
Association between sickle cell trait and low density parasitaemia in a P. falciparum malaria holoendemic region of Western Kenya
(University of Nairobi Institute of Tropical & Infectious Diseases (UNITID), Kenya, 2012)Aims: The frequency of the mutant gene for sickle cell is widely distributed in the sub- Saharan Africa, the Middle East, and the Indian subcontinent. There is epidemiologic evidence that sickle cell trait confers a ... -
Red blood cell immune complex binding capacity in children with sickle cell trait (HbAS) living in P. falciparum malaria holoendemic region of Western Kenya
(ARMY MEDICAL RESEARCH UNIT-KENYA APO NEW YORK 09675, 2013)Malaria infection leads to the formation of circulating immune complexes CICs which have been implicated in the pathogenesis of complicated malaria which includes severe malarial anemia. Children with sickle cell trait ... -
Sickle cell trait (HbAS) is associated with increased expression of erythrocyte complement regulatory proteins CR1 and CD55 levels in children
(International Journal of TROPICAL DISEASE & Health, 2013)Aims: Erythrocyte complement regulatory proteins, complement receptor 1 (CR1) and decay accelerating factor (CD55) protect red blood cells (RBCs) from complement mediated damage by controlling complement activation cascade ... -
Health & demographic surveillance system profile: the Kombewa health and demographic surveillance system (Kombewa HDSS)
(Oxford University Press, 2014)The Kombewa Health and Demographic Surveillance System (HDSS) grew out of the Kombewa Clinical Research Centre in 2007 and has since established itself as a platform for the conduct of regulated clinical trials, nested ... -
Pharmacokinetic evaluation of intravenous artesunate in adults with uncomplicated falciparum malaria in Kenya: a phase II study
(spring link, 2014)Background Alternatives to treatment for malaria treatment of travellers are needed in the USA and in Europe for travellers who return with severe malaria infections. The objective of this study is to show the pharmacokinetic ... -
The Benefits of research partnerships to the community at KEMRI/Walter Reed Project
(Dspace, 2015)Ethical Principles on Human Subject Protection in Clinical Research revolves around Autonomy, Beneficence and Justice. Beneficence requires that the benefits to research participants are maximized as you minimize the risk ... -
Genetic diversity and protective efficacy of the RTS, S/AS01 malaria vaccine
(Massachusetts Medical Society, 2015)BACKGROUND The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and has partial protective efficacy against clinical and severe malaria disease in infants and children. We investigated ...