Department of Biomedical Sciences: Recent submissions
Now showing items 61-80 of 95
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Sensitive detection of EBV microRNAs across cancer spectrum reveals association with decreased survival in adult acute myelocytic leukemia
(Scientific Report, 2019)Epstein Barr virus (EBV) is the etiologic agent involved in numerous human cancers. After infecting the host, EBV establishes a latent infection, with low levels of messenger RNA (mRNA) and protein expression, evolved ... -
Status of aflatoxin contamination in cow milk produced in smallholder dairy farms in urban and peri-urban areas of Nairobi County: a case study of Kasarani sub county, Kenya
(Taylor & Francis, 2018)Introduction: Milk consumption in Kenya supersedes other countries in East Africa. However, milk contamination with aflatoxin M1 (AFM1) is common, but the magnitude of this exposure and the health risks are poorly ... -
Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma
(Springer, 2017)Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of ... -
Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H
(BMC, 2020)Background: Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and ... -
Association between haematological parameters and sickle cell genotypes in children with Plasmodium falciparum malaria resident in Kisumu County in Western Kenya
(2020)Background: Sickle cell disease (SCD) is a monogenic disorder due to point mutation in the β-globin gene resulting in substitution of Valine for Glutamic acid. The SCD is prevalent in P. falciparum endemic regions such ... -
Epidemiological patterns and antimicrobial resistance of bacterial diarrhea among children in Nairobi City, Kenya
(RIGLD, Research Institute for Gastroenterology and Liver Diseases, 2020)Aim:Determine the prevalence of enteric bacterial pathogens and their antimicrobial resistance among diarrheic children in Nairobi City, Kenya. Background: Regardless of enteric bacterial pathogens being a major ... -
Ingestion of hemozoin by peripheral blood mononuclear cells alters temporal gene expression of ubiquitination processes
(Biochemistry and Biophysics Reports, 2022)Plasmodium falciparum (Pf) malaria is among the leading causes of childhood morbidity and mortality worldwide. During a natural infection, ingestion of the malarial parasite product, hemozoin (PfHz), by circulating phagocytic ... -
Pyrethroid resistance in Anopheles gambiae s.s. and Anopheles arabiensis in western Kenya: phenotypic, metabolic and target site characterizations of three populations
(Wiley Online Library, 2012)Field and laboratory investigations revealed phenotypic, target site and metabolic resistance to permethrin in an Anopheles gambiae s.s. (Diptera: Culicidae) population in Bungoma District, a region in western Kenya in ... -
Habitat selection and vertical inheritance drive archaeal community structure in arthropod guts
(ECOLOGICAL AND EVOLUTIONARY DRIVERS OF MICROBIAL COMMUNITY STRUCTURE IN TERMITE GUTS, 2015)The arthropod gut is streamlined to anaerobically mineralize mostly plant-derived organic matter. In only five major arthropod groups (millipedes, scarab beetle larvae, cockroaches, and lower and higher termites) are ... -
Compartment-specific bacterial communities in higher termites
(M icroha bitat-specificity of the hindgut microbiota in higher termites, 2013)The higher termite gut is a highly structured habitat and shows the presence of spatially separated compartments. The differences in physicochemical parameters between the compartments, most importantly pH, play an important ... -
Isolation and characterization of actinobacteria with potential for control of fusarium spp and colletotrichum kahawae
(Jomo Kenyatta University of Agriculture and Technology, 2007)Smallholder subsistence farming is important in the production of food crops for basic livelihoods and income generation in rural areas. However, yields have remained low due to high disease, weed and pest incidences. ... -
Isolation and characterization of Streptomyces species with antifungal activity from selected national parks in Kenya
(African Journal of Microbiology Research, 2010)Microorganisms and their natural products are potentially important for the biological control of crop diseases without detrimental effects to the environment. In this study, acetonitrile-methanol extracts of 361 ... -
Growth characteristics and production of secondary metabolites from selected novel Streptomyces species isolated from selected Kenyan national parks
(JKUAT ANNUAL SCIENTIFIC CONFERENCE PROCEEDINGS, 2010)The aim of study was to characterize growth of novel Streptomyces isolates as well as the secondary metabolites they were producing. Four Streptomyces isolates from Chyulu National Park (Chy 4 -10, Chy 15-10, Chy 15-5 and ... -
Optimization of growth conditions and characterization of enzymatic activity of selected novel Streptomyces species from Kenyan soils
(Scientific Conference Proceedings, 2012-06-14)This study was aimed at unveiling and assessing protease, esterase, amylase and lipase enzymes from selected novel Streptomyces species with biotechnological interest. Four Streptomyces isolates from Jomo Kenyatta University ... -
“Methanoplasmatales,” Thermoplasmatales-related archaea in termite guts and other environments, are the seventh order of methanogens
(American Society for Microbiology, 2012-12-01)The Euryarchaeota comprise both methanogenic and nonmethanogenic orders and many lineages of uncultivated archaea with unknown properties. One of these deep-branching lineages, distantly related to the Thermoplasmatales, ... -
Archaeal diversity and community structure in the compartmented gut of highert termites
(Philipps-Universität Marburg, 2013)Termites are phylogenetically divided into lower and higher termites (Inward et al., 2007). The higher termites, which constitute three quarter of all known termite species, are represented by only one family Termitidae, ... -
Metagenomic analysis of the microbiota in the highly compartmented hindguts of six wood-or soil-feeding higher termites
(BioMed Central, 2015-12-01)Termites are important contributors to carbon and nitrogen cycling in tropical ecosystems. Higher termites digest lignocellulose in various stages of humification with the help of an entirely prokaryotic microbiota housed ... -
Evaluation of cercaricidal and miracicidal activity of selected plant extracts agains larval stages of Schistosoma mansoni
(Journal of Natural Sciences Research, 2016)Schistosomiasis is a parasitic disease caused by blood-flukes of the genus Schistosoma. It is one of the most widespread of all human parasitic diseases, ranking second only to malaria in terms of its socioeconomic and ... -
CRITICAL FACTORS AND CREDIT UPTAKE IN YOUTH ENTERPRISE DEVELOPMENT FUND IN SUNA EAST CONSTITUENCY, MIGORI COUNTY, KENYA
(KENYATTA UNIVERSITY, 2018-11)Youth entrepreneurship in Kenya plays a significant role in enhancing Kenya’s economic development and in reducing youth unemployment. Despite the great significance of entrepreneurship in Kenya, there is a high failure ... -
CRITICAL FACTORS AND CREDIT UPTAKE IN YOUTH ENTERPRISE DEVELOPMENT FUND IN SUNA EAST CONSTITUENCY, MIGORI COUNTY, KENYA
(KENYATTA UNIVERSITY, 2018-11)Youth entrepreneurship in Kenya plays a significant role in enhancing Kenya’s economic development and in reducing youth unemployment. Despite the great significance of entrepreneurship in Kenya, there is a high failure ...
