Department of Medical Biochemistry: Recent submissions
Now showing items 141-160 of 282
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The Global Burden of Severe Falciparum Malaria: An Immunological and Genetic Perspective on Pathogenesis
(Springer, New York, NY, 2013)Plasmodium falciparum malaria is a leading global cause of morbidity and mortality of infectious disease origin. Here, we focus largely on P. falciparum malaria in sub-Saharan Africa since this geographic region bears the ... -
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
(BioMed Central, 2013-12-01)In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ... -
Duffy Antigen/Receptor for Chemokines (DARC): Is There a Role in Prostate Cancer?.
(American Society of Hematology, 2005-11-16)Introduction: The Duffy blood group antigens function as chemokine receptors and as receptors for several species of malarial parasites. Approximately 70% of African Americans are Duffy negative as a result of a single ... -
Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide
(Nature Publishing Group, 2019-04-17)Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia and initiation of treatment saves lives, especially in high-disease ... -
Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in …
(Elsevier, 2019-07-01)Background: Severe malarial anaemia (SMA) is a leading cause of childhood mortality in holoendemic Plasmodium falciparum regions. Methods: To gain an improved understanding of SMA pathogenesis, whole genome and transcriptome ... -
Evaluation of the Parasight platform for malaria diagnosis
(American Society for Microbiology Journals, 2017-03-01)The World Health Organization estimates that nearly 500 million malaria tests are performed annually. While microscopy and rapid diagnostic tests (RDTs) are the main diagnostic approaches, no single method is inexpensive, ... -
A novel ED-based sexual assault centre in western Kenya: description of patients and analysis of treatment patterns
(BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine, 2011-11-01)he aim of this study was to establish the feasibility of a Kenyan emergency department (ED)-based sexual assault centre; and to improve knowledge of the characteristics of sexual assault in the region. -
Quality Blood Sampling Techniques and Influence of Socio cultural Factors among ARVs Forces Community in Seeking Healthcare
(SMU Medical Journal, 2016-01)Project monitoring and evaluation (M/E) determines resource accountability and its impact to various stakeholders. Plenary project success requires holistic community participation and empowerment. However, this approach ... -
21 Days of Social Synergistic Pilot Survey on Community Participation to Determine the Level Virulence of COVID-19 in Africa before Re-Opening of the Education Sector in an …
(ACTA SCIENTIFIC MEDICAL SCIENCES, 2020-05)21 days of Synergistic community participation survey [2] to determine reopening of education sector in Africa remain a key cradle to create psycho social confidence in parents, pupils and students since they left school ... -
Assess Functionality of IMCI Spatial Facility Infrastructure and Policy Utilization in Trans-Nzioa County, Kenya
(Open Science Repository Medicine, 2013)Implementation of integrated management of childhood illness (IMCI), in a comprehensive and holistic approach, forms bench mark for basic child health in promoting celebration of fifth birth day for children below five ... -
Community participation in integrated water, sanitation & hygiene (WASH) programs in supply of safe water in Trans Nzioa, Kenya
(international knowledge sharing platform, 2014)37% of Developing world’s population lack access to clean water; 2.5 billion people lack improved basic sanitation and hygiene facilities, over 780 million people still use unsafe drinking water. Trans Nzioa County, ... -
Utilization of integrated management of childhood illnesses for child health in Western Kenya
(INTERNATIONAL JOURNAL OF NURSING DIDACTICS, 2015-01)Implementation of integrated management of childhood illness (IMCI) in comprehensive and holistic, forms bench mark for fifth birth day celebration for child health, free from Malaria, Pneumonia, Diarrhea, Measles and ... -
Sigmoid volvulus in pregnancy
(Annals of African Surgery., 2019)Sigmoid volvulus in pregnancy is a rare condition that poses a myriad of challenges in diagnosis and management of the patient. It demands on the clinician a high index of suspicion, immediate treatment involving resuscitation ... -
Adult Wilms Tumour in pregnancy
(East African medical journal, 2020)Wilms’ tumor (nephroblastoma) is the most common primary renal malignancy in children, with a peak presentation in the ages 3-4 years. Wilms’ tumor is extremely rare in adults with around 300 cases described in literature. ... -
National Health Laboratory Services in Kenya: challenges for the new millennium
(East African medical journal, 2001-07)I want to begin by expressing my gratitude to the Kenya Association of Clinical Pathologists for inviting me to this meeting and for making it possible for me to share this momentous occasion with friends and colleagues ... -
Severe hyponatraemia in hospital inpatients
(BMJ Publishing Group, 1978-12-09) -
The Kenya haemoglobin.
(East African medical journal, 1974)Haemoglobin Kenya is (at present) a rare haemoglobin variant, found so far only in the Luo tribe in Kenya. It came to light by its chance association with the Hb S trait, a situation giving rise to an unexpectedly high ... -
Hemoglobin Kenya, the product of a gamma-beta fusion gene: studies of the family.
(Elsevier, 1973-09)Recently, we reported the discovery of a new hemoglobin variant, Hb Kenya, in a 26-year-old Kenyan of the Nilotic Luo tribe [1]. Chemical characterization of the non-a chain of this hemoglobin showed that the amino ... -
The effect of α-thalassemia on the level of hybrid hemoglobin variants in heterozygotes
(Taylor & Francis, 1986-01-01)The influence of a relative deficiency in α chain production on the amount of Hemoglobins Kenya, P-Nilotic, and Lepore was determined. The level of these hybrid hemoglobins in heterozygotes was correlated to various states ... -
Haplotypes and α globin gene analyses in sickle cell anaemia patients from Kenya
(Blackwell Publishing Ltd, 1987-02)Over 60 patients from the Luo and Luhya tribes of Western Kenya, aged 1–23 years. with severe sickle cell anaemia were evaluated through haematological and gene mapping analyses. Nearly all (56 of 58 tested) were homozygous ...