School of Public health & Community Development: Recent submissions
Now showing items 361-380 of 411
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Clinical predictors of severe malarial anaemia in a holoendemic Plasmodium falciparum transmission area.
(British Journal of Haematology, 2005)Severe malarial anaemia (SMA) is a common complication of Plasmodium falciparum infections, resulting in mortality rates that may exceed 30% in paediatric populations residing in holoendemic transmission areas. One ... -
Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria
(AIDS, 2005)Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria -
Hematological predictors of increased severe anemia in Kenyan children coinfected with Plasmodium falciparum and HIV‐1
(Wiley Subscription Services, Inc., A Wiley Company, 2010-04-01)Malaria and HIV-1 are coendemic in many developing countries, with anemia being the most common pediatric hematological manifestation of each disease. Anemia is also one of the primary causes of mortality in children ... -
Turning point
(Nature Research, 2011-02-01)Collins Ouma became a molecular biologist to help thwart malaria's high mortality rate in his native Kenya. Last November, he won the Royal Society Pfizer award for his work on identifying genes that may confer protection ... -
Natural monocytic acquisition of haemozoin and rantes polymorphisms: association with malarial disease outcomes and functional changes in children from Wester...
(2011-08-15)Plasmodium falciparum is an important cause of morbidity and mortality in children residing in holoendemic transmission areas largely from severe malarial anaemia (SMA). Although overproduction of inflammatory-derived ... -
Polymorphic variability in the 3'untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falc...
(BioMed Central, 2011-08-06)Plasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young children ... -
Knowledge and behaviour as determinants of anti-malarial drug use in a peri-urban population from malaria holoendemic region of western Kenya
(BioMed Central, 2011-04-20)The appropriate use of anti-malarial drugs determines therapeutic efficacy and the emergence and spread of drug-resistant malaria. Strategies for improving drug compliance require accurate information about current ... -
Bacteremia in Kenyan children presenting with malaria
(American Society for Microbiology, 2011-02-01)Since the etiologies and clinical outcomes of bacteremia in children with Plasmodium falciparum infections, particularly in areas of holoendemic malaria transmission, are largely unexplored, blood cultures and comprehensive ... -
Polymorphisms in the Fc Gamma Receptor IIIA and Toll-Like Receptor 9 Are Associated with Protection against Severe Malarial Anemia and Changes in Circulating...
(Journals. ASm. org, 2012-10-08)An understanding of the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in the designing of a rationally based malaria vaccine. Variants within the Fc gamma receptors ... -
Dose-Effects of Bednets Impregnated with a Natural Pyrethrins Formulation: Persistence, Feeding Inhibition, and Wash Resistance against Anopheles gambiae ss
(2012)This study evaluated dose-response, persistence, irritancy and wash resistance of mosquito nets treated with a synergized natural pyrethrins-formulation against Anopheles gambiae ss Methods. Multi-filament polyester ... -
Polymorphisms in Fc gamma receptor (FcγRIIIA-176 F/V) and Toll-like receptor (TLR9 [-1237 T/C]) are associated with protection against severe malarial anemia an...
(American Society for Microbiology, 2012-10-08)Understanding the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in designing a rationally-based malaria vaccine. Variants within the Fc gamma receptors (FcγRs) mediate ... -
Communicating African spirituality through ecology: Challenges and prospects for the 21st century
(2012-06-19)This review was set in the context of African spirituality and ecology. Specifically, the review addressed issues of African spirituality and the environment from a Kenyan context. Through analyses on existing literature, ... -
Provider knowledge of treatment policy and dosing regimen with artemether-lumefantrine and quinine in malaria-endemic areas of western Kenya
(BioMed Central, 2012-12-29)Due to widespread anti-malarial drug resistance in many countries, Kenya included, artemisinin-based Combination Therapy (ACT) has been adopted as the most effective treatment option against malaria. Artemether-lumefantrine ... -
Functional Haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children
(Springer-Verlag, 2012-02-01)Development of protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variations in human FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect ... -
Effectiveness of Out-patient Therapeutic Program on Nutrition among Under Fives: A Retrospective Study of Kisumu East District, Kenya
(2013)Abstract Outpatient Therapeutic Program (OTP) has been implemented with great success. Monitoring and evaluation against program objectives is integral. This study aimed to assess effectiveness of OTP program in Kisumu ... -
(− 7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
(Bio Med Central, 2013)In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb)< 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ... -
EBNA-1 specific effector T cell deletion associated with holoendemic malaria exposure in the etiology of endemic Burkitt’s lymphoma (P3063)
(American Association of Immunologists, 2013-05-01)Etiological mechanism of eBL remain largely unknown despite long-standing epidemiological link between malaria and EBV co-infection. Age-dependent deficiency in EBV-specific CD8+ T cell-mediated IFN-γ immunosurveillance ... -
Factors in the management of feeding in nursery school children as perceived by their mothers in rural Bondo County, Kenya
(BioMed Central, 2013-11-15)The effects of malnutrition on health status and survival of children has been the subject of extensive research for several decades. Malnutrition affects physical growth, cognitive development of children, morbidity ... -
Modelling the Impact of Misdiagnosis and Treatment on the Dynamics of Malaria Concurrent and Co-infection with Pneumonia
(2013)Incidences of misdiagnosis of diseases with similar symptoms as malaria has increased lately due to the increasing levels of endemicity of these diseases and their co- infection with malaria. In this paper a mathematical ... -
Correlates of Behavior Management Strategies Among Learners With Autistic Spectrum Disorders In Primary Schools In Western Kenya
(2014)Practitioners handling learners with Autistic Spectrum Disorders (ASDs) often feel ill- prepared to effectively manage this disorder. Quite often, when faced with cases of challenging behaviour, teachers use coping ...